Online First
Musculoskeletal Medicine and Pain  |   August 2020
Opioid-induced Sickle Cell Crisis with Multiple, Life-threatening Complications
Author Notes
  • From the Department of Pediatrics (Dr Haggerty) and the Department of Emergency and Hospital Medicine, Division of Toxicology (Drs Koons, Beauchamp, Cook, Cannon, and Katz) at the Lehigh Valley Health Netowrk/University of South Florida Morsani College of Medicine (Lehigh Valley campus) in Bethlehem, Pennsylvania. 
  • The abstract from this article was presented at the American College of Medical Toxicology (ACMT) Annual Scientific Meeting, April 6-8, 2018 in Washington, DC and the PACEP18 Annual Scientific Assembly, March 20, 2018 in Harrisburg, PA. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Kenneth D. Katz, MD, EM Research, 4th Floor, South Wing, 2545 Schoenersville Road, Bethlehem, Pennsylvania 18017-7300. Email: Kenneth_D.Katz@lvhn.org
     
Article Information
Pain Management/Palliative Care / Opioids
Musculoskeletal Medicine and Pain   |   August 2020
Opioid-induced Sickle Cell Crisis with Multiple, Life-threatening Complications
The Journal of the American Osteopathic Association Published Online First on August 27, 2020. doi:https://doi.org/10.7556/jaoa.2020.125
The Journal of the American Osteopathic Association Published Online First on August 27, 2020. doi:https://doi.org/10.7556/jaoa.2020.125
Abstract

The risk of opioid use disorder among patients with sickle cell disease who are treated with chronic opioids remains unclear, but the complications associated with opioid use and overdose can be accentuated in those with sickle cell disease. In this case report, we describe a 13-year-old girl with sickle cell disease who presented to the emergency department after a morphine overdose causing renal infarction, acute kidney injury, acute respiratory distress syndrome, and posterior reversible encephalopathy syndrome.

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