Review  |   September 2020
Pathophysiologic Mechanisms of Concussion, Development of Chronic Traumatic Encephalopathy, and Emerging Diagnostics: A Narrative Review
Author Notes
  • From the Department of Neurosurgery at Riverside University Health System in Moreno Valley, California and Western University, College of Osteopathic Medicine, Department of Neurosurgery, Pomona, California. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to James A. D. Berry, DO, Riverside University Health System, 26520 Cactus Avenue, Moreno Valley, California 92555-3927. Email: jamesberrydo@gmail.com
     
Article Information
Emergency Medicine / Neuromusculoskeletal Disorders
Review   |   September 2020
Pathophysiologic Mechanisms of Concussion, Development of Chronic Traumatic Encephalopathy, and Emerging Diagnostics: A Narrative Review
The Journal of the American Osteopathic Association, September 2020, Vol. 120, 582-589. doi:https://doi.org/10.7556/jaoa.2020.074
The Journal of the American Osteopathic Association, September 2020, Vol. 120, 582-589. doi:https://doi.org/10.7556/jaoa.2020.074
Abstract

Pathophysiological mechanisms and cascades take place after a mild traumatic brain injury (mTBI) that can cause long-term sequelae, including chronic traumatic encephalopathy in patients with multiple concurrent TBIs. As diagnostic imaging has become more advanced, microanatomical changes present after mTBI may now be more readily visible. In this narrative review, the authors discuss emerging diagnostics and findings in mTBI through advanced imaging, electroencephalograms, neurophysiologic processes, Q2 biochemical markers, and clinical tissue tests in an effort to help osteopathic physicians to understand, diagnose, and manage the pathophysiology behind mTBI, which is increasingly prevalent in the United States.

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