Case Report  |   January 2020
Topical Imiquimod and Subsequent Erythema Multiforme
Author Notes
  • From the Sampson Regional Medical Center/Campbell University (Drs Maxfield and and Hansen) in Clinton, North Carolina; the Dermatology & Laser Center, Medical Center Clinic and the Department of Dermatology at Florida State University College of Medicine in Pensacola (Dr Gaston); and the University of Tennessee College of Medicine in Memphis (Ms Peck). Dr Maxfield is a third-year resident. 
  • Address correspondence to Luke Maxfield, DO, Sampson Regional Medical Center/Campbell University, 607 Beaman St, Clinton, NC 28328-2603. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
Article Information
Cardiovascular Disorders
Case Report   |   January 2020
Topical Imiquimod and Subsequent Erythema Multiforme
The Journal of the American Osteopathic Association, January 2020, Vol. 120, 45-48. doi:https://doi.org/10.7556/jaoa.2020.010
The Journal of the American Osteopathic Association, January 2020, Vol. 120, 45-48. doi:https://doi.org/10.7556/jaoa.2020.010
Web of Science® Times Cited: 1
Abstract

Topical imiquimod is commonly used in the nonsurgical management of actinic keratosis and superficial basal cell carcinoma. Although adverse effects have been limited primarily to local irritation, another rare adverse reaction is erythema multiforme. We present a case of erythema multiforme involving the oral mucosa, trunk, and extremities that followed broad application of topical imiquimod for the management of suspected superficial basal cell skin cancers and actinic keratosis. The patient had used imiquimod previously without complication. Cessation of use and systemic corticosteroids resulted in prompt clearance.

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