A 74-year-old man was referred to a neurologist by his primary care physician with symptoms including frequent falls, recurrent visual hallucinations, loss of smell and taste, and panic attacks. By exclusion, the neurologist diagnosed DLB. For the next 4 years, his symptoms progressed to include gait and vision problems, increasing cognitive deficits, speech and emotional issues, and changes in sensory input. Motor changes were characterized by festinating gait, ataxia, and loss of balance. The patient's ability to read was lost, and he had frequent visual hallucinations accompanied by loss of concentration, word-finding difficulty, and agnosia. Interestingly, he could differentiate musical instruments. The patient had difficulty with verbal expression and eventually adopted a blank stare. His family reported that he could “cry at the drop of a hat” and occasionally emoted angrily. The patient had sensory problems, and he could not distinguish between hot and cold. Near the end of his life, the patient developed a heightened startle response, was unable to easily breathe through the nose, and had worsening dysphagia. Three months before his death at the age of 78 years, the patient was nonambulatory, had taken in very little nutrition, and had become increasingly withdrawn. The death certificate listed “Advanced Lewy Body Dementia” as the cause of death. Per an advance discussion and consent by the family, the postmortem brain was removed for analysis.