SURF  |   June 2019
Osteopathic Cranial Manipulative Medicine and the Blood-Brain Barrier: A Mechanistic Approach to Alzheimer Prevention
Author Notes
  • From the Rowan University School of Osteopathic Medicine in Stratford, New Jersey. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Lauren J. Crispino, OMS II, Rowan University School of Osteopathic Medicine, 1 Medical Center Dr, Stratford, NJ 08084-1500. Email: crispinol2@rowan.edu
     
Article Information
Geriatric Medicine / Neuromusculoskeletal Disorders / Preventive Medicine
SURF   |   June 2019
Osteopathic Cranial Manipulative Medicine and the Blood-Brain Barrier: A Mechanistic Approach to Alzheimer Prevention
The Journal of the American Osteopathic Association, June 2019, Vol. 119, e25-e28. doi:10.7556/jaoa.2019.070
The Journal of the American Osteopathic Association, June 2019, Vol. 119, e25-e28. doi:10.7556/jaoa.2019.070
Abstract

Recent studies have demonstrated that blood-brain barrier (BBB) dysfunction may be implicated in the pathogenesis of Alzheimer disease, thus establishing a link between disease manifestation and compromised neurovasculature. The authors identify relationships between Alzheimer disease and BBB breakdown, the response of the BBB to increased cerebral blood flow and shear stress, and the impact of osteopathic cranial manipulative medicine on cerebrovascular hemodynamics. They propose and review a rationale for future research to evaluate osteopathic cranial manipulative medicine as a preventive treatment for patients with illnesses of neurovascular origin.

Subscribe to view more

For full access to this article, log in to an existing user account, purchase an annual subscription, or purchase a short-term subscription.

Order a subscription

Subscribe

Pay Per View

Entire Journal
30-Day Access

$50.00

Buy Now

This Issue
7-Day Access

$25.00

Buy Now

This article
24-Hour Access

$10.00

Buy Now

Sign In Or Create an account

Please sign in using your Osteopathic.org login.
If you do not have an AOA login, you may create a new account.

Or Subscribe