Case Report  |   March 2019
Death of a Fetus With Myeloproliferative Disorder and Trisomy 21
Author Notes
  • From the Department of Obstetrics and Gynecology at St Anthony Hospital in Oklahoma City, Oklahoma (Drs Prentice and Deiter) and the Perinatal Center of Oklahoma in Oklahoma City (Dr Stanley). Dr Prentice is a fourth-year resident. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Danielle Prentice, DO, St Anthony Hospital, 1000 N Lee Ave, Oklahoma City, OK 73102-1036. Email: dkirch8@gmail.com
     
Article Information
Obstetrics and Gynecology / Pediatrics / Psychiatry
Case Report   |   March 2019
Death of a Fetus With Myeloproliferative Disorder and Trisomy 21
The Journal of the American Osteopathic Association, March 2019, Vol. 119, 208-211. doi:https://doi.org/10.7556/jaoa.2019.032
The Journal of the American Osteopathic Association, March 2019, Vol. 119, 208-211. doi:https://doi.org/10.7556/jaoa.2019.032
Abstract

A 27-year-old woman, gravida 2, para 1, presented at 24 weeks gestation with an intrauterine death. She previously consulted with maternal-fetal medicine because of a high suspicion of trisomy 21 after abnormal maternal serum screen and cell-free DNA test results. The patient elected to have chromosomal analysis following the death of the fetus, which confirmed a trisomy 21 diagnosis. Placental pathologic findings suggested that the cause of fetal death was total occlusion of the major vessels due to the accumulation of myeloid precursor cells, a novel mechanism. This case report discusses the rare finding of myeloproliferative disorder as a cause of death of a fetus with trisomy 21.

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