Speelman DL. Nonpharmacologic Management of Symptoms in Females With Polycystic Ovary Syndrome: A Narrative Review. J Am Osteopath Assoc 2019;119(1):25–39. doi: https://doi.org/10.7556/jaoa.2019.006.
Download citation file:
Polycystic ovary syndrome is the most common hormone disorder in females of reproductive age, affecting reproductive, metabolic, and cardiovascular health. With an unknown cause and a spectrum of common signs and symptoms, diagnosis is based on consensus criteria, and treatment options often target individual symptoms, with variable effectiveness. Safe, effective complementary and alternative therapies can be used to manage symptoms. The first-line intervention is lifestyle modification, including weight loss when appropriate, with caloric restriction and exercise to maintain a healthy weight. Low-carbohydrate and/or low-glycemic index diets can provide additional benefits, and nutritional supplements may be useful adjuncts. The recommended physical activity regimen should include both aerobic and resistance exercise.
a The Rotterdam criteria8 for diagnosis of polycystic ovary syndrome (PCOS) require at least 2 of the 3 listed features.
b One of the criteria need to be present for hyperandrogenism.
c Polycystic ovaries are not a requirement for diagnosis of PCOS.
a All participants were women with PCOS unless otherwise noted.
Abbreviations: AUC, area under the curve; CHO, carbohydrate; HOMA-IR, homeostatic model assessment for insulin resistance; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; NEFAs, nonesterified fatty acids; PCOS, polycystic ovary syndrome; RCT, randomized controlled trial; T, testosterone.
b Chinese peony/common garden peony and Chinese licorice.
c Five herbal extracts: Cinnamomum verum, Glycyrrhiza glabra, Hypericum perforatum, Plactiflora, and Tribulus terrestris.
Abbreviations: AUC, area under curve; BMI, body mass index; BP, blood pressure; hCG, human chorionic gonadotropin; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; LH, luteinizing hormone; PCOS, polycystic ovary syndrome; RCT, randomized controlled trial; T, testosterone; TGs, triglycerides.
Abbreviations: A4, androstenedione; AMH, anti-Müllerian hormone; BMI, body mass index; DHHS, US Department of Health and Human Services; FAI, free androgen index; FSH, follicle-stimulating hormone; GLUT4, glucose transporter type 4; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment for insulin resistance; IR, insulin resistance; LH, luteinizing hormone; PCOS, polycystic ovary syndrome; PRT, progressive resistance training; RCT, randomized controlled trial; SHBG, sex hormone–binding globulin; T, testosterone; Vo2, oxygen consumption; Vo2max, maximum oxygen consumption.
This PDF is available to Subscribers Only
View Article Abstract & Purchase Options