Osteopathic physicians should encourage patients to be actively responsible for the day-to-day self-management of symptoms and look at all aspects of their lives (eg, their pain, feelings, beliefs, attitudes, social and emotional life, and social, cultural, or religious environments). Biopsychosocial forces challenge and dysregulate a person's homeostatic balance and inherent healing capacity, contributing to the onset and maintenance of chronic pain. Chronic pain syndrome is closely tied to somatic dysfunction. Although structure and function issues may trigger the initial report of pain, body unity issues, homeostatic dysfunctions, and dysregulation of autonomic nervous system worsen and perpetuate pain perception and distress.