Adelizzi RA, Wilkins Childs JC, Dabrow MB, Freed N. Splenic hypofunction in systemic lupus erythematosus. J Am Osteopath Assoc 1994;94(5):414. doi: 10.7556/jaoa.19220.127.116.114.
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Systemic lupus erythematosus is a relatively common autoimmune disease in the United States. Hyposplenism is infrequently described in patients with systemic lupus erythematosus. It is seen in up to 5% of patients and is thought to be caused by vasculitic changes within the spleen. The diagnosis of hyposplenism can be made easily by identifying Howell-Jolly bodies on a peripheral blood smear. The authors describe a patient with systemic lupus erythematosus associated with hyposplenism and discuss possible diagnostic and treatment implications.
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