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Results: The final analysis included 25 patients with FBSS; 15 patients were in the MBSR intervention arm, and 10 in the control group. At 12-week follow-up, patients in the intervention arm had a mean 7.0-point increase (on an 108-point scale) in pain acceptance and quality of life on the Chronic Pain Assessment Questionnaire, a mean 3.6-point decrease (on a 24-point scale) in functional limitation on the Roland-Morris Disability Questionnaire, a mean 6.9-point reduction (on a 30-point scale) in pain level on the Summary Visual Analog Scale for Pain, a mean 1.5-point reduction (on a 4-point scale) in frequency of use and potency of analgesics used for pain and recorded on logs, and a mean 2.0-point increase (on a 5-point scale) in sleep quality on the abridged Pittsburgh Sleep Quality Inventory. These results were statistically and clinically significant compared to outcomes for the control group.