Twenty-one healthy volunteers (8 women, 13 men) aged 23 to 32 years (mean [SEM] body mass index, 24 [3.7]) gave written consent and participated in the present study. No volunteers were excluded from the study. Differences in baseline measurements (group mean [SEM]) for the augmentation technique, suppression technique, and sham therapy were not statistically significant for heart rate (69 [15], 71 [23], 66 [9] beats/min), mean blood pressure (79 [2], 77 [3], 76 [3] mm Hg), SaO
2 (98 [1], 97 [1], 97 [1]%), left S
CTO
2 (65 [9], 66 [10], 66 [10] %), or right S
CTO
2 (66 [11], 67 [10], 67 [10] %) (
Table 2). Heart rate, blood pressure, and SaO
2, remained constant during the cranial OMM techniques and sham therapy (
Figure 1). Neither augmentation (left: 0.10 [0.05] %/min,
R2=0.56,
P=.144; right: 0.06 [0.05] %/min,
R2 = 0.33,
P=.314) nor sham therapy (left: -0.06 [0.02]%/min,
R2=0.68,
P=.084; right: -0.10 [0.05] %/min,
R2=0.54,
P=.156) affected cerebral tissue oxygenation. Cerebral tissue oxygenation was decreased in left (-0.33 [0.08] %/min,
R2=0.85,
P=.026) and right (-0.37 [0.06] %/min,
R2=0.94,
P=.007) prefrontal lobes by the suppression technique (
Figure 2).