▪ Probabilities of Primary Endpoint Event‡ | | | |
□ FRS >10% | | | |
– Probability of primary endpoint event | | | |
Statin group | ... | 0.0031 (0.0024-0.0037) | Ridker§ (Author assumption) |
Standard management group | ... | 0.0054 (0.0043-0.0065) | Ridker§ (Author assumption) |
□ FRS ≤10% | | | |
– Probability of primary endpoint event | | | |
Statin group | ... | 0.0011 (0.0009-0.0013) | Ridker§ (Author assumption) |
Standard management group | ... | 0.0020 (0.0016-0.0024) | Ridker§ (Author assumption) |
– Probability of adverse event∥ | ... | 0.014 (0.008-0.02) | AstraZeneca23 (Author assumption) |
▪ Costs, mean | | | |
□ Outpatient costs, statin group | | | |
– Office visit (CPT 99213) | ... | $61.31 | CMS24 |
– Lipid panel | ... | $19.01 | CMS25 |
– Alanine aminotransferase | ... | $10.44 | CMS25 |
– Asparate aminotransferase | ... | $10.20 | CMS25 |
– hs-CRP | ... | $25.55 | CMS25 |
– Venipuncture | ... | $3.00 | CMS25 |
–Total initial outpatient cost¶ | ... | $129.51 ($103.61-$155.41) | ¶ (Author assumption) |
– Total incremental outpatient cost# | ... | $32.38 ($25.90-$38.85) | # (Author assumption) |
□ Outpatient costs, standard management group | | | |
– Office visit (CPT 99213) | ... | $61.31 | CMS24 |
– Lipid panel | ... | $19.01 | CMS25 |
– hs-CRP | ... | $25.55 | CMS25 |
– Venipuncture | ... | $3.00 | CMS25 |
– Total initial outpatient cost¶ | ... | $108.87 ($87.10-$130.64) | ¶ (Author assumption) |
– Total incremental outpatient cost# | ... | $27.22 ($21.77-$32.66) | # (Author assumption) |
□ Other costs | | | |
– Rosuvastatin, 20 mg/tablet | ... | $4.11 ($0.13-$5.00) | Red Book23 (Author assumption) |
– Primary endpoint event | ... | $13,123 ($5397-$26,770) | ** (Author estimate) |
– Nonfatal myocardial infarction | 0.14 | $6891.39 ($4459.66-$9951.16) | CMS26,27 (Author estimate) |
– Nonfatal stroke | 0.19 | $7973.14 ($4327.86-$14,727.25) | CMS26,27 (Author estimate) |
– Arterial revascularization | 0.45 | $20,581.76 ($9809.11-$39,200.54) | CMS26,27 (Author estimate) |
– Hospitalization for unstable angina | 0.10 | $2549.85 ($2039.88-$3059.82) | CMS26,27 (Author estimate) |
– Death from cardiovascular causes | 0.12 | $7599.23 ($0.00-$39,200.54) | †† (Author estimate) |
▪ Health Utilities‡‡ | | | |
□ Primary endpoint event | ... | 0.606 (0-1) | ** |
□ Nonfatal myocardial infarction | 0.14 | 0.704 | Sullivan and Ghushchyan28 |
□ Nonfatal stroke | 0.19 | 0.650 | Sullivan and Ghushchyan28 |
□ Arterial revascularization | 0.45 | 0.6995 | Author estimate |
□ Hospitalization for unstable angina | 0.10 | 0.695 | Sullivan and Ghushchyan28 |
□ Death from cardiovascular causes | 0.12 | 0 | Author assumption |
□ Healthy/no event | ... | 1.00 (0.90-1.00) | Author assumption |