Hoegerl C, Zboray S. Pathological Laughter in a Patient With Multiple Sclerosis. J Am Osteopath Assoc 2008;108(8):409–411. doi: https://doi.org/10.7556/jaoa.2008.108.8.409.
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Pseudobulbar affect—such as pathological laughter or crying—is associated with several different neurologic diseases and is most frequently seen in patients with Alzheimer disease. However, many physicians do not recognize it as a symptom associated with multiple sclerosis. The present report describes a case of pathological laughter in a 56-year-old man who was diagnosed as having multiple sclerosis 20 years earlier.
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