Corrections  |   September 2006
Article Information
Corrections   |   September 2006
The Journal of the American Osteopathic Association, September 2006, Vol. 106, 529. doi:
The Journal of the American Osteopathic Association, September 2006, Vol. 106, 529. doi:
The American Osteopathic Association's Division of Research Development regrets that the incorrect text was published with the following abstract: 

Oxenberg JC, Smith R, Troutman D, Greene C, KriebelR. Addition of laminin and fibronectin to SIS used as conduits in peripheral nerve repair. J Am Osteopath Assoc. 2006;106: 485–486. C18. Available at: Accessed September 21, 2006.

The correct text for this clinical studies abstract should have appeared as shown below: 
Addition of Laminin and Fibronectin to SIS Used as Conduits in Peripheral Nerve Repair
Jacqueline C. Oxenberg, MS III,1 Ryan Smith, DO, MBA,2 Douglas Troutman, MS III,1 Richard Kriebel, PhD,1 Charlotte Greene, PhD1; 1Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131; 2Tripler Army Medical Center, Honolulu, HI 
This is a pilot study using laminin and fibronectin as an additive to small intestine submucosa (SIS) grafts used to repair transected sciatic nerve in a rat model. Previous studies in our lab have shown sciatic nerve regeneration to be successful using SIS grafts without growth factors. SIS is a biological material that may be used to correct problems of larger peripheral nerve gap injuries and improve regrowth by acting as a natural guide between the proximal and distal segments of the nerves, providing the proper growth environment with minimal antigenicity, thus decreasing chances of rejection. Other studies have shown the addition of fibronectin to various types of grafts further enhanced nerve regeneration by promoting Schwann cell growth. The goal of this study is to determine whether adding laminin and/or fibronectin to SIS grafts improves sciatic nerve regeneration. The experimental group had a 10 mm segment of the right sciatic nerve resected followed by placement and suturing of and SIS graft plus laminin and/or fibronectin laced in the gap as a conduit for nerve regeneration. The control group had the right sciatic nerve resected and reattached directly. Schwann cell growth and nerve regeneration were assessed using anti-s100 antibody, and fast cresyl violet stain to assess Schwann cell migration and neuron regeneration respectively. Preliminary results indicated that: 
  1. Schwann cell migration and accompanying neuron infiltration occurred up to approximately 2.5 cm over the 6-month healing time in experimental animals.
  2. Healing in control animals was observed to be inhibited by the formation of collagen scar tissue.
  3. Gait analyses show increased sciatic function in experimental groups of laminin and/or fibronectin compared to control groups.
These results exceed previously reported rates of peripheral nerve regeneration using non-SIS graft materials and show addition of laminin and/or fibronectin improve both sciatic nerve regeneration and sciatic function in gait analyses. 
The August 2006 issue of the has been corrected online to reflect this change. In addition, the abstract, as reprinted in the final program for the 50th Annual American Osteopathic Association Research Conference, has been corrected in advance of publication: 

AOA Council on Research. Osteopathic Medicine in the American Health Care System, Las Vegas, Nev, 16–18 October 2006. Chicago, Ill: American Osteopathic Association; 2006.

This poster is entered in the Student Prize Competition, a judged event that takes place during the Poster Session at the Research Conference.