Manfredonia JF. Prescribing Methadone for Pain Management in End-of-Life Care. J Am Osteopath Assoc 2005;105(3_suppl):18S–21S. doi: .
Download citation file:
Methadone hydrochloride is an effective, inexpensive, and relatively safe opioid to use in the treatment of patients with chronic pain. It is especially effective in management of pain during the final stages of life, as it is the only long-acting analgesic available in liquid form. However, because methadone has a long half-life, individual wide variations, and potential for accumulation and overdosage, physicians must judiciously and conscientiously prescribe it. Also, they should closely monitor patients during the titration phase and educate them with regard to basic pharmacologic properties and potential side effects. A plan to start at low doses and proceed slowly is applicable to methadone.
This PDF is available to Subscribers Only
View Article Abstract & Purchase Options