Review  |   November 2018
Cardiovascular Disease as a Result of the Interactions Between Obesity, Climate Change, and Inflammation: The COCCI Syndemic
Author Notes
  • From the Touro University College of Osteopathic Medicine-CA in Vallejo. Drs Clearfield and Shubrook are investigators in the National Institutes of Health Cardiovascular Inflammation Trial. 
  • Disclaimer: Jay H. Shubrook, an associate editor of The Journal of the American Osteopathic Association, was not involved in the editorial review or decision to publish this article. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Jay H. Shubrook, DO, Touro University College of Osteopathic Medicine-CA, 1310 Club Dr, Mare Island, Vallejo, CA 94592-1187. Email: jay.shubrook@tu.edu
     
Article Information
Cardiovascular Disorders / Preventive Medicine
Review   |   November 2018
Cardiovascular Disease as a Result of the Interactions Between Obesity, Climate Change, and Inflammation: The COCCI Syndemic
The Journal of the American Osteopathic Association, November 2018, Vol. 118, 719-729. doi:10.7556/jaoa.2018.157
The Journal of the American Osteopathic Association, November 2018, Vol. 118, 719-729. doi:10.7556/jaoa.2018.157
Abstract

Obesity and climate change conspire to create an environment in which subclinical vascular inflammation leads to progressive atherosclerosis, which contributes to the number 1 cause of global mortality: cardiovascular disease. The syndemic model requires 2 or more diseases or contributors to disease (such as obesity and climate change) clustering within a specific population in addition to the associated societal and social factors, ultimately creating an environment supportive of a greater adverse interaction. This article explores the syndemic of obesity and climate change as a driver for cardiovascular disease.

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