Review  |   September 2018
Resveratrol's Potential in the Adjunctive Management of Cardiovascular Disease, Obesity, Diabetes, Alzheimer Disease, and Cancer
Author Notes
  • From the Midwestern University/Chicago College of Osteopathic Medicine (Student Doctor Kulashekar and Dr Peuler) and the Department of Biomedical Sciences at Midwestern University (Ms Stom) in Downers Grove, Illinois. 
  • Financial Disclosures: None reported. 
  • Support: This work was supported by funds from the Biomedical Sciences Program and the Department of Pharmacology at Midwestern University. 
  •  *Address correspondence to Jacob D. Peuler, PhD, Midwestern University/Chicago College of Osteopathic Medicine, 555 31st St, Downers Grove, IL 60515-1235. Email: jpeule@midwestern.edu
     
Article Information
Cardiovascular Disorders / Endocrinology / Geriatric Medicine / Diabetes
Review   |   September 2018
Resveratrol's Potential in the Adjunctive Management of Cardiovascular Disease, Obesity, Diabetes, Alzheimer Disease, and Cancer
The Journal of the American Osteopathic Association, September 2018, Vol. 118, 596-605. doi:10.7556/jaoa.2018.133
The Journal of the American Osteopathic Association, September 2018, Vol. 118, 596-605. doi:10.7556/jaoa.2018.133
Abstract

Resveratrol is a naturally occurring polyphenol that can be found in several human dietary sources, including red wine; many plants, especially grapes, berries, and nuts; and nutritional supplements. Findings from numerous preclinical experiments and clinical trials in humans suggest that resveratrol may play an important role in managing or preventing a variety of diseases. Some of the health benefits include cardioprotective effects; chemopreventive properties; metabolic changes, such as improved glycemic control; protection from diabetic consequences; and synergistic therapeutic effects when administered with other treatment modalities. Resveratrol has been found to be safe and reasonably well tolerated in humans, with mild to moderate gastrointestinal side effects. This review provides a summary of recent preclinical experiments and clinical trials pertaining to the effects of resveratrol on cardiovascular disease, obesity, diabetes, Alzheimer disease, and cancer. It also identifies suggested mechanisms by which resveratrol functions and presents issues surrounding resveratrol concentrations in vitro vs plasma levels reported in vivo.

Subscribe to view more

For full access to this article, log in to an existing user account, purchase an annual subscription, or purchase a short-term subscription.

Order a subscription

Subscribe

Pay Per View

Entire Journal
30-Day Access

$30.00

Buy Now

This Issue
7-Day Access

$15.00

Buy Now

This article
24-Hour Access

$5.00

Buy Now

Sign In Or Create an account

Please sign in using your Osteopathic.org login.
If you do not have an AOA login, you may create a new account.

Or Subscribe