Brief Report  |   August 2018
Osteopathic Manipulative Therapy and Multiple Sclerosis: A Proof-of-Concept Study
Author Notes
  • From the Departments of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health at the University of Genoa in Italy (Drs Cordano, Pardini, Sassos, Infante, Lapucci, Cellerino, and Calabro); the Department of Neurology at the University of California, San Francisco (Dr Cordano); the Italian Multiple Sclerosis Foundation in Genoa, Italy (Dr Tacchino); the European Institute of Osteopathic Medicine in Genoa, Italy (Ms Armezzani, Mr Veroni, and Mr Ciullo); and the Department of Neurology at Johns Hopkins University School of Medicine in Baltimore, Maryland (Dr Nourbakhsh). 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Christian Cordano, MD, PhD, University of California, San Francisco Department of Neurology, 675 Nelson Rising Ln, San Francisco, CA 94143-0003. Email: cordanochristian@gmail.com
     
Article Information
Neuromusculoskeletal Disorders / Osteopathic Manipulative Treatment / Psychiatry
Brief Report   |   August 2018
Osteopathic Manipulative Therapy and Multiple Sclerosis: A Proof-of-Concept Study
The Journal of the American Osteopathic Association, August 2018, Vol. 118, 531-536. doi:10.7556/jaoa.2018.121
The Journal of the American Osteopathic Association, August 2018, Vol. 118, 531-536. doi:10.7556/jaoa.2018.121
Abstract

Context: Research on the effect of osteopathic manipulative therapy (OMTh; manipulative care provided by foreign-trained osteopaths) on chronic symptoms of multiple sclerosis (MS) is lacking.

Objective: To evaluate the effect of OMTh on chronic symptoms of MS.

Methods: Patients with MS who were evaluated at the neurology clinic at Genoa University in Italy were recruited for this study. Participants received 5 forty-minute MS health education sessions (control group) or 5 OMTh sessions (OMTh group). All participants completed a questionnaire that assessed their level of clinical disability, fatigue, depression, anxiety, and quality of life before the first session, 1 week after the final session, and 6 months after the final session. The Extended Disability Status Scale, a modified Fatigue Impact Scale, the Beck Depression Inventory-II, the Beck Anxiety Inventory, and the 12-item Short Form Health Survey were used to assess clinical disability, fatigue, depression, anxiety, and quality of life, respectively.

Results: Twenty-two participants were included in the study (10 in the control group and 12 in the OMTh group). In the OMTh group, statistically significant improvements in fatigue and depression were found 1 week after the final session (P=.002 and P<.001, respectively). An increase in quality of life was also found in the OMTh group 1 week after the final session (P=.36).

Conclusion: Results demonstrate that OMTh should be considered in the treatment of patients with chronic symptoms of MS.

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