Clinical Images  |   September 2017
Löffler Endocarditis and Endomyocardial Fibrosis
Author Notes
  • From the Department of Internal Medicine (Drs Flanigan, Velez, Ruden, and Lilly) and the Division of Cardiovascular Medicine (Drs Velez, Ruden, and Lilly) at Ohio State University in Columbus. 
  • Financial Disclosures: None reported. 
  • Support: None reported. 
  •  *Address correspondence to Matthew J. Flanigan, MD, 395 W 12th Ave, Columbus, OH 43210-1252. E-mail: matthew.flanigan@osumc.edu
     
Article Information
Cardiovascular Disorders / Imaging / Clinical Images
Clinical Images   |   September 2017
Löffler Endocarditis and Endomyocardial Fibrosis
The Journal of the American Osteopathic Association, September 2017, Vol. 117, 601. doi:10.7556/jaoa.2017.115
The Journal of the American Osteopathic Association, September 2017, Vol. 117, 601. doi:10.7556/jaoa.2017.115
A 65-year-old man presented to a medical center with dyspnea, peripheral edema, and orthopnea. Diagnosis of chronic systolic and diastolic biventricular heart failure secondary to Löffler endocarditis and endomyocardial fibrosis was made. A transthoracic echocardiograph showed a reduced left ventricular ejection fraction and severe right ventricular systolic dysfunction. The right ventricular cavity was nearly obliterated by a homogeneous mass, and spectral Doppler ultrasonography demonstrated diminished antegrade systolic flow across the pulmonic valve. Anticoagulation therapy with heparin was initiated. Cardiac magnetic resonance image revealed diffuse hyperenhancement of the right ventricular free wall on delayed gadolinium enhancement (image A, arrow). Catheterization of the right side of the heart with contrast ventriculogram revealed a nearly obliterated (image B, dotted line) right ventricle with interatrial passage of contrast and subsequent left ventricular opacification (image B, arrows). A 35-cm ultrasound-accelerated thrombolysis catheter was placed in the left pulmonary artery. Hemodynamic measurements demonstrated atrialization of the right ventricular pressure waveform. Hemodynamics failed to improve after 18 hours of thrombolysis, and the patient died of complications of biventricular heart failure 10 days after presentation. 
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