Review  |   July 2016
Clinical Relevance and Mechanisms of Antagonism Between the BMP and Activin/TGF-β Signaling Pathways
Author Notes
  • From the Division of Biomedical Science at Marian University College of Osteopathic Medicine in Indianapolis, Indiana. 
  •  *Address correspondence to Jonathan W. Lowery, PhD, 3200 Cold Spring Rd, EC317E, Indianapolis, IN 46222-1960. E-mail: jlowery@marian.edu
     
Article Information
Emergency Medicine / Neuromusculoskeletal Disorders / Pediatrics / Pulmonary Disorders
Review   |   July 2016
Clinical Relevance and Mechanisms of Antagonism Between the BMP and Activin/TGF-β Signaling Pathways
The Journal of the American Osteopathic Association, July 2016, Vol. 116, 452-461. doi:10.7556/jaoa.2016.089
The Journal of the American Osteopathic Association, July 2016, Vol. 116, 452-461. doi:10.7556/jaoa.2016.089
Web of Science® Times Cited: 1
Abstract

The transforming growth factor β (TGF-β) superfamily is a large group of signaling molecules that participate in embryogenesis, organogenesis, and tissue homeostasis. These molecules are present in all animal genomes. Dysfunction in the regulation or activity of this superfamily’s components underlies numerous human diseases and developmental defects. There are 2 distinct arms downstream of the TGF-β superfamily ligands—the bone morphogenetic protein (BMP) and activin/TGF-β signaling pathways—and these 2 responses can oppose one another’s effects, most notably in disease states. However, studies have commonly focused on a single arm of the TGF-β superfamily, and the antagonism between these pathways is unknown in most physiologic and pathologic contexts. In this review, the authors summarize the clinically relevant scenarios in which the BMP and activin/TGF-β pathways reportedly oppose one another and identify several molecular mechanisms proposed to mediate this interaction. Particular attention is paid to experimental findings that may be informative to human pathology to highlight potential therapeutic approaches for future investigation.

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