Case Report  |   June 2016
Disseminated Varicella-Zoster Virus After Vaccination in an Immunocompetent Patient
Author Notes
  • From the Division of Hospital Internal Medicine (Drs Scotch and Budavari), the Department of Dermatology (Dr Hoss), and the Division of Infectious Diseases (Dr Orenstein) at Mayo Clinic in Phoenix, Arizona. Dr Orenstein is the editor in chief of the American Osteopathic Association and was not involved in the editorial review or decision to publish this article. 
  •  *Address correspondence to Allison H. Scotch, MD, MPH, 13400 E Shea Blvd, Scottsdale, AZ 85259-5452. E-mail: scotch.allison@mayo.edu
     
Article Information
Preventive Medicine
Case Report   |   June 2016
Disseminated Varicella-Zoster Virus After Vaccination in an Immunocompetent Patient
The Journal of the American Osteopathic Association, June 2016, Vol. 116, 402-405. doi:10.7556/jaoa.2016.082
The Journal of the American Osteopathic Association, June 2016, Vol. 116, 402-405. doi:10.7556/jaoa.2016.082
Web of Science® Times Cited: 26
Abstract

Severe adverse events associated with varicella-zoster virus (VZV) vaccination are rare. The authors describe a 53-year-old woman with no known immunodeficiency who presented with diffuse pruritic rash 17 days after receiving the varicella virus vaccine live. She had a low level of white blood cells and received a diagnosis of thrombocytopenia with elevated aminotransferase levels. Punch biopsy demonstrated positive VZV immunostaining and viral culture positive for VZV. After treatment with acyclovir, her rash improved and her white blood cell and platelet counts returned to normal. Mild reactions to vaccines including localized rash are well recognized. Disseminated infections have been reported in patients with congenital and acquired immunodeficiency, but systemic postvaccination infections are rare in immunocompetent adults. This case highlights the importance of recognizing adverse events associated with vaccination.

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