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Supplement Article  |   August 1999
NSAIDs and the gastrointestinal tract: An update on recent progress
Article Information
Supplement Article   |   August 1999
NSAIDs and the gastrointestinal tract: An update on recent progress
The Journal of the American Osteopathic Association, August 1999, Vol. 99, S10-S13. doi:10.7556/jaoa.1999.99.8.S10
The Journal of the American Osteopathic Association, August 1999, Vol. 99, S10-S13. doi:10.7556/jaoa.1999.99.8.S10
Abstract

This article outlines the mechanisms involved in specific cyclooxygenase-l (COX-1) and cyclooxygenase-2 (COX-2) inhibition as they relate to the safety of nonsteroidal anti-inflammatory drug (NSAID) use. New advancements in COX-2 technology appear to improve the safety profile of NSAID therapy. Gastroenterologic issues such as ulcer disease and liver disease as related to .these novel new medications are reviewed.