Silverman GJ. NSAIDs and the gastrointestinal tract: An update on recent progress. J Am Osteopath Assoc 1999;99(8_suppl):S10-S13. doi: 10.7556/jaoa.1999.99.8.S10.
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This article outlines the mechanisms involved in specific cyclooxygenase-l (COX-1) and cyclooxygenase-2 (COX-2) inhibition as they relate to the safety of nonsteroidal anti-inflammatory drug (NSAID) use. New advancements in COX-2 technology appear to improve the safety profile of NSAID therapy. Gastroenterologic issues such as ulcer disease and liver disease as related to .these novel new medications are reviewed.
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