Elnabtity MH, Singh RF, Ansong MA, Craig TJ. Leukotriene modifiers in the management of asthma. J Am Osteopath Assoc 1999;99(7_suppl):S1–S6. doi: 10.7556/jaoa.1999.99.7.S1.
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Leukotrienes play a major role in the underlying pathophysiology of asthma. Leukotriene-receptor antagonists and direct leukotriene-synthesis inhibitors may be important new agents in maintenance therapy for asthma. Their role may also extend to attenuating exercise-induced and allergen-induced bronchospasm. This article reviews the effectiveness of available leukotriene modifiers in various clinical studies, reviews their adverse effects profile, and discusses their potential roles in the management of asthma.
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