Review  |   October 2015
Non–Vitamin K Antagonist Oral Anticoagulants: The Clinician’s New Challenge
Author Notes
  • From the Division of Trauma, Burn, and Surgical Critical Care at Brigham and Women’s Hospital in Boston, Massachusetts (Dr Yorkgitis), the Department of Surgery at Temple University Hospital in Philadelphia, Pennsylvania (Dr Zhang), and the Department of Surgery at Maine Medical Center in Portland, Maine (Dr Rappold). 
  •  *Address correspondence to Brian K. Yorkgitis, PA-C, DO, Division of Trauma, Burn, and Surgical Critical Care, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115-6110. E-mail: byorkgitis@partners.org
     
Article Information
Cardiovascular Disorders / Hypertension/Kidney Disease / Neuromusculoskeletal Disorders / Preventive Medicine
Review   |   October 2015
Non–Vitamin K Antagonist Oral Anticoagulants: The Clinician’s New Challenge
The Journal of the American Osteopathic Association, October 2015, Vol. 115, 612-621. doi:10.7556/jaoa.2015.122
The Journal of the American Osteopathic Association, October 2015, Vol. 115, 612-621. doi:10.7556/jaoa.2015.122
Abstract

Millions of US patients are prescribed oral anticoagulants. Traditionally, oral anticoagulation was achieved with vitamin K antagonists (VKAs). In recent years, non–VKA oral anticoagulants (NOACs) have emerged that provide an effective and convenient alternative to VKAs. These agents possess very different pharmacologic properties from what the medical community has grown accustom to with the VKAs. Thus, a new knowledge base is required for NOACs. One particular challenge with the NOACs is the lack of specific reversal agent, resulting in difficulties correcting the coagulopathy induced by these drugs when needed. A review of the current literature is presented to assist clinicians in gaining knowledge of the NOACs to care for patients.

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