Wieting J, Dykstra D, Ruggiero M, Robbins G, Galusha K. Central nervous system ischemia after varicella infection and desmopressin therapy for enuresis. J Am Osteopath Assoc 1997;97(5):293. doi: 10.7556/jaoa.19220.127.116.113.
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A 7-year-old boy had a left-sided cerebrovascular accident 48 hours after beginning intranasal desmopressin acetate (DDAVP) therapy for persistent secondary nocturnal enuresis and approximately 2 weeks after varicella infection. A possible connection between desmopressin therapy or varicella infection (or both) and the patients neurologic symptoms is discussed, as is the relationship of desmopressin with hypercoagulability, Suggestions for patient/parent education, medical history taking, and patient surveillance are offered to prescribing physicians.
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