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Case Report  |   April 1993
Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma
Article Information
Case Report   |   April 1993
Cortical blindness and seizures possibly related to cisplatin, vinblastine, and bleomycin treatment of ovarian dysgerminoma
The Journal of the American Osteopathic Association, April 1993, Vol. 93, 502. doi:10.7556/jaoa.1993.93.4.502
The Journal of the American Osteopathic Association, April 1993, Vol. 93, 502. doi:10.7556/jaoa.1993.93.4.502
Abstract

Ovarian dysgerminoma is the most common ovarian malignancy in young women. Conservative treatment is indicated in the reproductive-age woman who wishes to preserve childbearing capacity. This case report describes a patient with ovarian dysgerminoma who underwent chemotherapy with a cisplatin-vinblastine-bleomycin regimen that resulted in serious toxic complications--including cortical blindness and seizures--that were transient in nature. Although current chemotherapy regimens have dramatically improved the overall survival of women with germ-cell tumors, there are toxic complications such as those demonstrated in this report, and toxicity must be balanced against presumed benefit.