JJ Esper, MA Nigro, R Wishnow, T Barnett, AL Perrotta, W Richardson. Clinical improvement of the myopathy in eosinophilia-myalgia syndrome with steroids and rehabilitative therapy. J Am Osteopath Assoc 1992;92(8):1056. doi: 10.7556/jaoa.19220.127.116.116.
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The authors report a case of eosinophilia-myalgia syndrome with a progressive neuromyopathy. Progressive weakness, myalgia, and dermatitis developed in the patient described after chronic ingestion of high-dose L-tryptophan for insomnia. Laboratory, electrophysiologic, and muscle biopsy results support the diagnosis of an inflammatory myopathy consistent with that of eosinophilia-myalgia syndrome. The patient's weakness led to wheelchair dependency. A review of the literature regarding this disorder shows inconsistent results with steroid and other modes of therapy. After a course of high-dose steroids with long-term tapering and vigorous inpatient and outpatient rehabilitation, the patient was able to walk and function independently within 2 months.
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