Garmon R, Zemenick R. Acute severe asthma: Part 2. Current therapy. J Am Osteopath Assoc 1992;92(3):343. doi: 10.7556/jaoa.19188.8.131.523.
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Acute severe asthma is an extremely common and serious public health problem in the United States. Current optimum therapy of acute severe asthma includes supplemental oxygenation, nebulized beta-adrenergic receptor agonist therapy, and prompt use of glucocorticosteroids. In view of its low therapeutic index and the availability of more effective, less toxic agents, theophylline is no longer considered a first-line treatment. Ipratropium bromide combined with beta-agonist may augment bronchodilator responsiveness.
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