Free
Case Report  |   June 1991
Coumarin-induced skin necrosis
Article Information
Case Report   |   June 1991
Coumarin-induced skin necrosis
The Journal of the American Osteopathic Association, June 1991, Vol. 91, 601. doi:10.7556/jaoa.1991.91.6.601
The Journal of the American Osteopathic Association, June 1991, Vol. 91, 601. doi:10.7556/jaoa.1991.91.6.601
Abstract

Coumarin skin necrosis is a rare and usually unpredictable complication of coumarin therapy, occasionally leading to death. Onset is usually between the third and sixth day of coumarin therapy. The patient most commonly complains of pain in a region of abundant subcutaneous fat, with progression to erythema, petechiae, and gangrenous necrosis. Thrombosis of the dermal and the subcutaneous veins is demonstrated pathologically. We describe a case and review the pathogenesis, treatment, and prevention of this lesion.