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Case Report  |   October 1989
Acute myelofibrosis: report of a case and review of current literature
Article Information
Case Report   |   October 1989
Acute myelofibrosis: report of a case and review of current literature
The Journal of the American Osteopathic Association, October 1989, Vol. 89, 1323. doi:10.7556/jaoa.1989.89.10.1323
The Journal of the American Osteopathic Association, October 1989, Vol. 89, 1323. doi:10.7556/jaoa.1989.89.10.1323
Abstract

Acute myelofibrosis is a rare hematologic disorder characterized by pancytopenia, normal erythrocyte morphology, extensive marrow fibrosis, and a rapidly fatal clinical course. The etiology of this disease is unknown, but the malignant cell may be of megakaryocytic lineage. Although allogeneic bone marrow transplantation may be effective in achieving complete hematologic remission, optimal management of this rare and often rapidly fatal disease remains to be defined.