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Primary gallbladder cancer has a reported incidence of 0.5%, but appears to be increasing, resulting in 6,500 deaths annually. It nearly always is diagnosed at a late stage. Adenocarcinoma is the predominant cell type. The five-year survival rate is a dismal 1% to 12%. Reported here are five cases identified over an 18-month period among 206 patients who underwent cholecystectomies.
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