Edward H. Tobe. Importance of Neuroplasticity Changes in Mood Disorder. J Am Osteopath Assoc 2011;111(4):298–300. doi: 10.7556/jaoa.2011.111.4.298.
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...there is wide acknowledgement of an increase in mental ill-health at a global level. The authoritative work undertaken by WHO and the World Bank indicates that by the year 2020 depression will constitute the second largest cause of disease burden worldwide (Murray & Lopez, 1996) [expressed in terms of disability-adjusted life-years].... Positive mental health is a set of key domains encompassing well-being and positive states of mind. It is an integral part of health, including positive physical health. It can co-occur with and influence the onset, nature and outcomes of physical and mental illnesses.
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