John V. Ashurst, Megan N. Wasson, William Hauger, William T. Fritz. Pathophysiologic Mechanisms, Diagnosis, and Management of Dapsone-Induced Methemoglobinemia. J Am Osteopath Assoc 2010;110(1):16–20. doi: 10.7556/jaoa.2010.110.1.16.
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Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis. Methemoglobinemia, a potentially life-threatening condition in which the oxygen-carrying capacity of blood in body tissues is reduced, is a known adverse effect of dapsone use. The authors report a case of dapsone-induced methemoglobinemia observed in the emergency department during routine workup for contact dermatitis in a patient with celiac disease. The pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia are discussed.
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