Free
Articles  |   December 2001
Role of infection in Alzheimer's disease
Article Information
Geriatric Medicine / Neuromusculoskeletal Disorders
Articles   |   December 2001
Role of infection in Alzheimer's disease
The Journal of the American Osteopathic Association, December 2001, Vol. 101, 1S-6S. doi:
The Journal of the American Osteopathic Association, December 2001, Vol. 101, 1S-6S. doi:
Abstract

Alzheimer's disease (AD) is a chronic condition in which inflammation has been shown to contribute to neurodegeneration. Current thinking suggests that deposition of beta-amyloid in the brain promotes inflammation resulting in neuronal damage/death. Alternatively, our data suggest that chronic inflammation observed in late-onset sporadic AD may be stimulated by infection with the obligate, intracellular bacterium, Chlamydia pneumoniae. Our results indicate that C. pneumoniae is found in high frequency in glial cells in areas of neuropathology within the brains of patients with AD. Based on our evidence, nervous system infection with C. pneumoniae should be considered a risk factor for sporadic AD.